To make the most of LGD-3303, a potent selective androgen receptor modulator (SARM), understanding the right dosage is key. Achieving the ideal balance between reaping benefits and avoiding potential side effects requires a closer look at the science behind LGD 3303 dosage.
In this guide, we’ll break down the optimal amounts for bodybuilders, offer insights for both male and female users, and highlight the importance of a well-structured cycle. Whether you’re an experienced PED user or new to performance enhancers, getting the LGD-3303 dosage right is essential for reaching your fitness goals.
WHAT IS LGD 3303?
LGD-3303, not to be confused with Ligandrol, was developed by Ligand Pharmaceuticals to treat muscle wasting conditions and osteoporosis.
The preclinical and anecdotal information about this SARM is very limited. Those who have used it describe it as a dry counterpart of Ligandrol because it can blow you up in size without causing any water retention.
Unfortunately, LGD 3303 is one of the hardest selective androgen receptor modulators to come across, and paradoxically, the supply is unable to meet the demand.
It can be bought from legitimate vendors from time to time, but it always runs out of stock in record time because of its insane muscle building potential.
LGD 3303 DOSAGE
Researchers use anywhere from 5mg to 20mg a day but the sweet spot that most male users prefer is 10mg a day. Because the half-life is unclear, we recommend dosing twice per day.
Some users have tried doses of up to 20mg a day, but the benefits don’t seem to get any better past 10mg a day and only the side-effects increase, so high doses of LGD 3303 seem to cause diminishing returns.
Female users can get amazing results with as little as 2.5mg a day, and they should never use more than 5mg a day.
LGD 3303 HISTORY
The pharmaceutical company responsible for the development of LGD 3303 (commonly mistyped as LGD 3033) is Ligand Pharmaceuticals. They originally developed it for the treatment of muscle wasting conditions and osteoporosis approximately 15 years ago. Since then, it has gone through numerous animal trials and, most importantly, clinical trials.
In a 2009 a controlled trial with female rats, LGD 3303 showed a dose-dependent improvement in total lean body mass and physical function and was well tolerated. The scientists concluded that LGD 3303 may be useful in the prevention and/or treatment of muscle wasting associated with cancer and other chronic diseases. [R]
Unfortunately, subsequent clinical trials did not achieve the desired results, decreasing the chances of Ostarine becoming an approved prescription medication for the treatment of muscle wasting and osteoporosis.
HOW DOES LGD 3303 WORK?
Like all SARMs, LGD 3303 works by attaching to the androgen receptor in muscle tissue and bones. There, it stimulates protein synthesis to accelerate muscle growth and bone density.
This mechanism of action is similar to that of Anabolic Steroids, but the difference is that Anabolic Steroids are not selective for muscle gain and they attach to androgen receptors in all kinds of tissues, whereas SARMs are as selective for muscle and bone mass as possible
LGD 3303 BIOAVAILABILITY
In the context of bioavailability and absorption, a study conducted on a castrated rat model of androgen deficiency provides valuable insights. Despite potent activity on the levator ani muscle, LGD 3303 exhibited partial agonist effects on the preputial gland and ventral prostate, showcasing tissue-selective behavior.
Intriguingly, even with oral or continuous infusion dosing, maintaining this tissue selectivity was observed, emphasizing the compound’s unique pharmacokinetic properties.
Notably, the abstract suggests that LGD 3303’s tissue-selective activity is independent of its pharmacokinetic profile, pointing towards altered molecular interactions at the androgen receptor level as the primary mechanism. This finding underscores the complexity of LGD 3303’s bioavailability and absorption, suggesting that its unique tissue-specific effects are driven by more than just its distribution in the body.
HOW TO BUY LGD 3303 LEGALLY
LGD 3303 is a legal performance enhancing drug. Given that is has not been approved by the FDA, LGD 3303 can be classified as a research chemical. Research chemicals are completely legal to buy and sell online and over-the-counter, as long as they are being marketed as research products for laboratory use only and not for human consumption.
LGD 3303 PROS & CONS IN A NUTSHELL
PROS:
- WILL IMPROVE STRENGTH EXPONENTIALLY
- WILL PROVIDE A DRY, HARD AND VASCULAR LOOK
- WILL INCREASE BONE DENSITY AND JOINT STRENGTH
- WILL EXPONENTIALLY INCREASE RECOVERY
CONS:
- WILL SUPPRESS TESTOSTERONE LEVELS DRAMATICALLY
- WILL CAUSE DYSLIPIDEMIA (CHOLESTEROL FLUXUATIONS)
- WILL CAUSE VERY MILD LIVER TOXICITY
BENEFITS OF LGD 3303
The benefits of LGD 3303 have turned this therapeutic solution for muscle wasting diseases into one of the best, and definitely the most popular, performance enhancing drugs and anabolics for intermediate and experienced users alike. Whether one is trying to bulk up, get shredded or heal an injury, LGD 3303 is a great option.
These are the main benefits of LGD 3303:
FAST MUSCLE GROWTH
Due to its lack of water retention and its ability to retain and even increase muscle on a caloric deficit, it could be used effectively during a cutting cycle, but using it for that purpose would be a waste of its full muscle retention and building potential. [R]
STRENGTH INCREASE
FAT LOSS DISCLAIMER
INCREASED BONE DENSITY & JOINT STRENGTH
RECOVERY
As the powerful anabolic that it is, LGD-3303 will speed up recovery times and reduce muscle soreness, gain muscle back, and allow you to re-train any muscle group a lot sooner than you would be able to as a natural.
COSMETIC BENEFITS
Given the lack of water retention, you can expect your muscles to fill out while retaining a dry and hard look. It can be argued that LGD 3303 provides the best of both worlds: The volume and size that a wet compound would give, with the dry, hard and veiny look that a cutting agent would cause.
You can expect to be walking around with a pump 24/7, and your muscles will certainly have a full 3D look that few oral anabolics can provide.
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SIDE-EFFECTS OF LGD 3303
Unfortunately, LGD 3303 is not side-effect-free. The amazing benefits you just learned about come with some negatives but thankfully with the help of our guidance, it can still be one of the safest SARMs and performance enhancing drugs you can use.
TESTOSTERONE SUPPRESSION
- Decreased libido
- High blood pressure
- Weaker erections
- Reduced sex drive
- Lethargy
- Lack of motivation
- Irritability
- Testicular atrophy
- Testicular pain
DYSLIPIDEMIA
LIVER TOXICITY
OTHER SIDE-EFFECTS
Keep in mind that due to how rarely this SARM is used, there may be more side-effects that we do not know of, but the following side-effects can happen to anyone who uses SARMs and messes with his hormonal balance:
GYNECOMASTIA
The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen levels and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take LGD 3303.
HAIR SHEDDING
This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding, and LGD 3303 is no exception.
INSOMNIA
This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.
SARMs impact everyone differently. You may grow a third testicle, but your friend’s testicles may fall off during a cycle of LGD 3303. You never know what’s going to happen.
HOW TO AVOID & REVERSE SIDE-EFFECTS
HOW TO CYCLE LGD 3303
The most common LGD 3303 cycle consists in 10mg a day, taken for a total of 8 weeks. The shortest LGD 3303 cycles are usually around 4 weeks, and the longest ones can last for up to 10 weeks.
We really believe that 10mg a day for 8 weeks is the best approach to using LGD-3303, since it’s a protocol that allows most people to get amazing results without experiencing seriously nasty side-effects.
These cycles are ALWAYS followed by a 4 week Post-Cycle Therapy, preferrably with Clomiphene or Enclomiphene.
LGD-3303 ON-CYCLE SUPPORT
It’s imperative you use a testosterone base with your LGD 3303.
We can’t recommend Amino Asylum Enclomiphene enough. While using LGD 3303, a simple 12.5mg/day protocol of Enclomiphene can help keep your testosterone levels balanced, not causing any of the nasty symptoms from suppression or worse, a crash.
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LGD 3303 POST-CYCLE THERAPY (PCT)
Since LGD-3303 can suppress testosterone levels to a potentially large extent, we recommend all users take a PCT supplement or chemical for their Post-Cycle Therapy (PCT) after an LGD 3303 cycle to restore natural testosterone levels and ensure the retention performance enhancement of muscle gains, strength, and optimal sexual function.
The typical LGD 3303 PCT consists of 4 weeks of Enclomiphene (Androxal) or Clomiphene (Clomid) use. You can learn more about the ideal PCT for SARMs here.
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LGD 3303 TL:DR
In a nutshell, we could say that LGD 3303 is one of the most (if not the most) incredibly effective SARMs that will build a significant amount of muscle mass and bone strength.
A testosterone base, like Enclomiphene (Androxal) is needed to keep hormone levels stable throughout the cycle and even post-cycle. Clomiphene (Clomid) is another great option to use for a post-cycle.
This is an excellent option for intermediates or advanced PED users who want to get their feet wet with PEDs but also for experienced enhanced lifters who simply want to use something as close to AAS (Steroids) that will still provide great results without the nasty side-effects of AAS.
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