WHAT IS MK-677?
MK-677 (also known as Ibutamoren, Nutrobal and Oratrope) is an oral Growth Hormone Secretagogue and an agonist of the Ghrelin Receptor. It was developed by Reverse Pharmacology for the treatment of growth hormone deficiency, muscle wasting conditions, and osteoporosis.
This is an extremely popular compound used as a replacement for regular HGH injections. It is not as powerful as elevated doses of HGH, but it is way cheaper, rarely faked, and orally bioavailable. This is a versatile PED that can be added to pretty much any cycle, whether you are cutting, bulking, maintaining or just trying to recover from an injury.
Often misinterpreted, MK-677 is NOT a SARM but a secretagogue, similar to a Growth Hormone Releasing Peptide (GHRP) like GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Many just put this chemical under the umbrella class of SARMs as it can be used synergistically with practically any SARM, AAS (Steroid), or other PED (performance enhancing drug) on the market.
MK-677 (IBUTAMOREN) HISTORY
In 2017, Ammonett Pharma LLC receives a US patent to proceed with their brand drug Oratrope, a pill-form MK-677 [R].
In 2018, Lumos Pharma acquired the license for Ibutamoren (MK-677) [R]; they then referred to the compound as LUM-201.
MK-677 is currently under investigation for the treatment of growth hormone deficency and frailty in the elderly [R].
HOW TO BUY MK-677 LEGALLY
MK-677 is a legal performance enhancing drug. Given that is has not been approved by the FDA, MK-677 can be classified as a research chemical. Research chemicals are completely legal to buy and sell online and over-the-counter, as long as they are being marketed as research products for laboratory use only and not for human consumption.
You can find high-quality, 3rd-party purity-tested MK-677 by clicking in the link below. Use code ENH10 to save 10%!
HOW DOES MK-677 WORK?
MK-677 works by activating the ghrelin receptor with IGF-1 feedback preventing excess GH production. Increased levels of GH stimulates protein synthesis to accelerate muscle growth and bone density.
It may be possible to enhance the effects of MK-677 by using Huperzine A. According to some “broscientists”, it can inhibit somatostatin, a hormone that limits GH production, allowing MK-677 to increase GH levels even more. There is no scientific data to prove that Huperzine A can actually do this, but there are anecdotal reports from people who experienced a noticeable increase in the intensity of Ibutamoren’s effects after introducing Huperzine A at 250 micrograms a day (more tips like this can be found in our guide towards the bottom of this page).
MK-677 PROS & CONS IN A NUTSHELL
- VERY ANABOLIC DUE TO IGF-1 INCREASES
- WILL IMPROVE STRENGTH NOTICEABLY
- FAT LOSS THROUGH LIPOLYSIS
- WILL INCREASE BONE DENSITY AND JOINT STRENGTH
- FASTER RECOVERY
- INCREASED HUNGER
- BETTER SLEEP
- NUTRIENT PARTITIONING
- COSMETIC BENEFITS: MUSCLES FULLNESS, HAIR, SKIN, & NAILS
- INCREASED FASTING BLOOD SUGAR LEVELS (CAN CAUSE PRE-DIABETES)
- EXTREME HUNGER
- TINGLING/NUMBNESS TO EXTREMITIES (HANDS, FEET, ETC)
- WATER RETENTION
- HIGH BLOOD PRESSURE
- CARCINOGENESIS EFFECTS ON EXISTING CANCER
- INCREASED PROLACTIN LEVELS
- MINIMAL TESTOSTERONE SUPPRESSION
Don’t let this list of cons that’s just as large as the pros discourage you! Keep reading to find out more about them and how you can mitigate the side-effects completely.
While more clinical research is underway with MK-677 benefits and side-effects, we’ve compiled A LOT (thousands) of responses and blood panels from our community to come up with a semi-exhaustive list for you.
It will, however, provide a new muscle growth pathway that together with SARMs or steroids will maximize your results. Furthermore, Ibutamoren has been proven to be anti-catabolic, so it will help preserve muscle on a caloric deficit [R].
STRENGTH AND PERFORMANCE
If you intend to use MK-677 for fat loss, I would suggest taking it before bed at least 3 hours after your last meal, followed by 3-4 hours of fasting after you wake up the next day.
This is because lipolysis can only occur when insulin levels are low, and this is best achieved through fasting. Doing cardio in the morning, during the 3-4 hours of fasting, will significantly increase fat loss.
BONE DENSITY & JOINT STRENGTH
Note that in some instances, the water retention caused by Ibutamoren can be too heavy and it can have a negative impact on the joints, causing them to feel stiff.
RECOVERY AND HEALING
Many people claim that Ibutamoren has fixed chronic pain in some areas of their body, and it will definitely boost the speed at which your body heals itself (whether it be skin damage, skin burns, bone fractures, injured joints, etc…).
Some users report no extra hunger when they take Ibutamoren before bed, so if you want to benefit from the increased hunger, take Ibutamoren first thing in the morning.
The sleep improvement caused by Ibutamoren is one of its best properties. You can expect REM sleep to be deeper and last for longer, and you will almost certainly wake up more refreshed and energized the next morning [R].
According to some people, 6 hours of sleep on Ibutamoren are as effective, refreshing and energizing as 8 hours of normal sleep.
This benefit will also contribute to muscle growth, fat loss and injury recovery.
If you are very lean, water retention can fill you out and make your muscles pop but expect to lose some definition if you are on a calorie surplus. On a calorie deficit, the water retention is almost non-existent.
Ibutamoren will also improve the quality and appearance of your hair and skin [R].
Unfortunately, MK-677 is not without side-effects and while the list may look as exhaustive as the benefits, most of these side-effects of MK-677 can be mitigated through proper dosing, timing, food consumption, and supplementation (more on all of this in the On-Cycle Therapy chapter).
INSULIN SENSITIVITY/BLOOD SUGAR LEVELS
INCREASED BLOOD PRESSURE
If you didn’t know, excessive water retention can cause high blood pressure.
MK-677 will NOT cause cancer. However, if a user already has cancer (whether he is aware of it or not), Ibutamoren will speed up the growth and development of his cancer cells [R].
PROLACTIN & OTHER SIDE-EFFECTS
PROLACTIN LEVEL INCREASES
HOW TO AVOID & REVERSE SIDE-EFFECTS
MK-677 DOSAGE FOR BODYBUILDING
Bodybuilders use anywhere from 10mg to 30mg a day of MK-677 but the sweetspot that most male users prefer is 20mg a day.
Female users can get amazing results with as little as 10mg a day, and they should never use more than 20mg a day.
HOW TO CYCLE MK-677
The most common MK-677 dose on a cycle consists of 20mg, split twice a day, taken for a total of 12 weeks or one full dose of MK-677 at 20mg taken at night before bed. The shortest MK-677 cycles are usually around 6 weeks (during a PCT) and the longest ones can last for up to 24 weeks.
MK-677 can be taken anywhere from 6 weeks to 24 weeks at 20mg/day.
We really believe that 20mg a day for 12 weeks is the best approach to using MK-677, since it’s a protocol that allows most people to get amazing results without experiencing seriously nasty side-effects. This allows the user to take it synergistically with a SARM or AAS and finish it with the Post-Cycle Therapy that cycle calls for as well.
MK-677 ON-CYCLE THERAPY
It’s imperative to do your research before administering chemicals like MK-677. While the benefits outweigh the side-effects in our opinion, there sometimes is a cost to research no matter what you do.
In this section, we’ll discuss many of the side-effects of MK-677 we touched on above and how to mitigate or at least control them.
PREVENTING MK-677 PROLACTIN-INDUCED GYNOCEMASTIA & ERECTILE DYSFUNCTION
As we learned above, increased levels of Prolactin can not only cause gynecomastia but also erectile dysfunction in men [R].
We recommend using Vitamin B6 (P5P form) at 100mg before bed every single day of the cycle. Do this even if you think you are not prone to gyno, as this dose of P5P will not have any negative side-effects and will also have a good impact on overall health and sleep quality. If B6 does not work, try Cabergoline at 0.25mg every 3 days or Pramipexole at 0.125mg a day.
If sexual dysfunction persists, we recommend having Sildenafil (Viagra) on-hand while your prolactin levels start to decrease from the above supplementation. We’d like to note that vasodilators like Sildenafil or Tadalafil also help reduce blood pressure (effective when water retention is occurring); the very thing Tadalafil was designed for (until doctors realized it greatly improved sexual function).
INCREASING INSULIN SENSITIVTY ON MK-677
No one wants to raise their blood sugar levels and for sure no one wants to acquire Type 2 Diabetes. Typically, at-most, only fasted blood sugar levels will be elevated but in case one was predisposed to Type 2 Diabetes or becoming pre-diabetic, we recommend the following protocol.
The low insulin sensitivity (aka insulin resistance) and high blood sugar levels caused by MK-677 can be mitigated by taking 2 days off every week. For example, you can take MK-677 from Monday to Friday, stay off it during the weekend, and then resuming its use the next Monday. Alternatively, you can do 4 weeks on 1 week off.
If you do not want to take breaks, you can fight this side-effect by supplementing with Berberine (or a more advanced glucose disposal agent) at 300 to 500mg before a carbohydrate-heavy meal.
Alternatively, you can use Ashwagandha (250-500mg 2-3 times a day), Chromium Picolinate (200 micrograms 3 times a day) or Cinnamon Bark (600mg twice a day). Timing these supplements before carb-loaded meals is key for optimal results.
If you are using Ibutamoren on a calorie deficit for the purpose of losing fat, you can do intermittent fasting and/or decrease your carbohydrate intake to achieve better results while also keeping insulin resistance and high blood sugar in check.
In a nutshell, we could say that MK-677 is an incredibly effective research chemical that will not only by itself effectively build muscle and improve recovery but synergistically stack with any SARM or AAS to optimize progress even further.
WHERE TO BUY MK-677
If you’ve decided to research with MK-677 and want to find the best MK677 for sale, choosing a reliable company to buy from is crucial, since buying it from a bad company could result in you getting no results or getting horrible side-effects due to being sold something that’s not actually MK-677.
We recommend going with Chemyo MK-677.
All of their SARMs and research chemicals come in 50 ml (milliliter) bottles, which is a full 20 ml more than the industry standard of 30 ml—that’s a 66% increase in the value you’re getting with these products.
Key benefits of Chemyo:
- Third Party Testing
- Very Good Prices
- Responsive Customer Support
- Wide Range of Products
- Big Cryptocurrency Discount
They have been in the game for half a decade and have truly become one of the most reputable and most respected providers for 99.9% pure SARMs and other research chemicals.
You can buy MK-677 from them through the link below and use code ENH10 to save 10% off your order
Anywhere from 4 to 24 weeks.
For a standard bodybuilding cycle: 12 weeks
During a PCT: 4-6 weeks
Post-injury recovery: up to 24 weeks
No. It's a growth hormone (GH) secretagogue.
It's often placed under the umbrella of SARMs since it's a research chemical that can be used as an effective treatment for muscle wasting diseases like SARMs can.
It can cause carcinogenesis which is the speeding up of the spread of cancer that one already had to have prior to MK-677.
Elevated prolactin levels due to MK-677 can cause erectile dysfunction (a symptom of high prolactin). If you have a history of high prolactin during the use of anabolics, use precaution when taking MK-677.
The study done on mice can be misconstrued. Humans aren't injecting MK-677 and they certainly aren't infusing it into their brains.
These studies show that even chronic ghrelin receptor agonism did not alter anxiety or expression of fear memories [R].