Table of Contents
The best Post Cycle Therapy for SARMs has EVERYTHING to do with a class of drugs called SERMs. In SERMs 101, we’ll learn what a SERM is, how to use it for SARMs, what is the best PCT for SARMs, and lastly, where to buy SERMs for your SARMs post cycle.
If you’re just skimming, and looking for the #1 SARMs website to purchase PCTs from, we highly recommend Amino Asylum. Their high-quality products are second to none, and their shipping is ALWAYS on time.
BENEFITS:
- Reduce Cholesterol
- Prevent and/or Reverse Gynecomastia
- Increase Testosterone Levels
Use the code “Enhanced20” for an exclusive 20% discount
WHAT ARE SERMs?
SERMs (Selective Estrogen Receptor Modulators) are a class of drugs commonly used for the treatment of breast cancer, osteoporosis and infertility in women. SERMs are also employed by male bodybuilders, who use them to restore their endogenous hormone production after SARM/Steroid cycles (Post-Cycle Therapy) as well as to prevent and reverse gynecomastia.
SELECTIVE ESTROGEN RECEPTOR MODULATORS IN BODYBUILDING
SERMs can stimulate endogenous Testosterone production in males by blocking the hypothalamic estrogen receptor. This action tricks the brain into thinking that estrogen levels are low, and since estrogen is primarily acquired through the aromatization of Testosterone, the hypothalamus secretes GnRH which stimulates the pituitary causing it to release LH and FSH which boost Testosterone levels and sperm production.
ARE SERMS SAFE?
SERMs in general have been shown to be relatively safe and well tolerated. Drugs like Bazedoxifene (Duavee) have been clinically studied for treatment of osteoporosis in postmenopausal women at increased risk of fracture. They show no breast or endometrial stimulation and in the first two years with patients taking drugs like Tamoxifen, the small increase is better in venous thromboembolism, and similar in the long term to other SERMs. [R]
In short, yes. SERMs studies have been heavily peer-reviewed and have proven their efficacy with little-to-no severe side-effects. More on the side-effects below.
SERMs SIDE-EFFECTS
While the risk of acquiring any side-effect(s) while using SERMs is low, we want our community to be fully knowledgeable about any potential dangers along the way in their research.
We also want to note here that many of the more severe effects were only shown to effect 1% of women taking various SERMs for years; all of which already had severe-to-fatal illnesses they were combating.
DIFFERENT SERMs SIDE-EFFECTS
IGF-1 REDUCTION
Tamoxifen (so far) is the only SERM that can lower IGF-1, one of the most anabolic hormones in the human body. This can limit gains in muscle mass, but it can easily be avoided by using MK-677. [R]
MOOD SWINGS AND SEXUAL DYSFUNCTION
Clomiphene is infamous for causing terrible mood swings, anxiety and depression in a very significant percentage of users.
Despite providing a modest increase in sexual function in some users, it is also possible for SERMs to have a negative impact on sex drive and erectile function. Mind you, many of the effects you’ll read here are empirical (not proven).
HOT FLASHES AND NIGHT SWEATS
SERMs can cause both hot flashes and night sweats in a small percentage of users. [R]
BLOOD CLOTS
Tamoxifen was proven to increase the chances of developing deep vein thrombosis (DVT) and pulmonary embolism (PE) in elderly women with breast cancer. Mind you, these studies have been done compiling data from Danish and Taiwanese databases. However, if you have a family history of DPV or PE, stay away from Tamoxifen and only use it for short periods of times if absolutely necessary. Fortunately, this is a rare side-effect, even in women with breast cancer who take Tamoxifen for years. [R]
MILDLY LIVER TOXIC
SERMs can potentially increase AST and ALT levels, but having a significant degree of liver toxicity due to most SERMs is extremely unlikely. Running N-Acetyl Cysteine (NAC) during PCT is always advisable. [R]
VISUAL DISTURBANCES
As show in this study, Clomiphene caused visual disturbances such as blurring, spots and flashes in a small percentage of subjects. According to this paper, these side-effects subsided after discontinuing Clomiphene. [R]
HOW SERMS WORK
SERMs work by selectively blocking estrogen receptors such as those found in the breasts and the hypothalamus. By antagonizing ERs in the breasts, SERMs prevent estrogen from attaching to these receptors and causing the growth of breast cancer in females or gynecomastia in males. By the same token, blocking ERs in the hypothalamus allows SERMs to trick the brain into thinking that there is no estrogen in the body, causing it to stimulate testosterone production.
Even though all SERMs have the same mechanism of action, their effects differ slightly, making some more suitable for the treatment of gynecomastia, and others more effective at restoring / boosting testosterone production.
DO SARMS NEED A PCT?
PCT FOR SARMs
Not all SARMs need a PCT. It’s best to run a post cycle therapy (PCT) after a SARMs cycle to get your natural testosterone levels back up to normal. While on cycle, your body will lower testosterone production because of the SARMs binding to androgen receptors, blocking out testosterone. Certain SARMs are more suppressive to testosterone production than others, although most of them are not as suppressive as an average steroid.
The only reliable way of determining whether a SARM needs a PCT or not is to get a blood test. If a blood test just isn’t in the cards for your research, it’s best to err on the side of caution and match the appropriate SERM with your SARM/AAS cycle.
The most common PCTs consist of Nolvadex (Tamoxifen) and Clomid (Clomiphene). With that being said, there are few instances where one would use neither and instead use Raloxifene (Evista).
Some factors that affect these decisions could include type of SARM, dosage, cycle length, and genetic predispositions. We go into greater detail in our SERM Profiles.
DIFFERENT SERMs FOR PCT
TAMOXIFEN (NOLVADEX) – PCT
PROS:
- WILL PREVENT GYNECOMASTIA
- MAY REVERSE GYNECOMASTIA
- WILL INCREASE TESTOSTERONE LEVELS
- WILL REDUCE CHOLESTEROL
- WILL PREVENT OSTEOPOROSIS
CONS:
- WILL DECREASE IGF-1 LEVELS
- MAY CAUSE MOOD SWINGS (RARE)
- MAY CAUSE LOW LIBIDO (RARE)
- MAY CAUSE HOT FLASHES (RARE)
CLOMIPHENE (CLOMID) – PCT
PROS:
- MAY PREVENT GYNECOMASTIA
- WILL INCREASE TESTOSTERONE LEVELS SIGNIFICANTLY
CONS:
- WILL DECREASE IGF-1 LEVELS
- MAY CAUSE MOOD SWINGS (COMMON)
- MAY CAUSE LOW LIBIDO (RARE)
- MAY CAUSE HOT FLASHES (COMMON)
- MAY CAUSE VISUAL DISTURBANCES (RARE)
RALOXIFENE (EVISTA) – PCT
PROS:
- WILL PREVENT GYNECOMASTIA
- WILL REVERSE GYNECOMASTIA (BETTER THAN TAMOXIFEN)
- WILL PROVIDE A SMALL INCREASE IN TESTOSTERONE LEVELS
- WILL REDUCE CHOLESTEROL
- WILL PREVENT OSTEOPOROSIS
CONS:
- WILL DECREASE IGF-1 LEVELS
- MAY CAUSE MOOD SWINGS (RARE)
- MAY CAUSE LOW LIBIDO (RARE)
- MAY CAUSE HOT FLASHES (RARE)
ENCLOMIPHENE (ANDROXAL) – PCT
PROS:
- MAY PREVENT GYNECOMASTIA
- WILL PROVIDE A DRAMATIC INCREASE IN TESTOSTERONE LEVELS
- MAY BUILD MUSCLE MASS
- WILL INCREASE SEX DRIVE SIGNIFICANTLY
CONS:
- WILL DECREASE IGF-1 LEVELS
- MAY CAUSE AGGRESSION (COMMON)
- MAY CAUSE VISUAL DISTURBANCES (RARE)
As you can see, each SERM is slightly better at different things, with Raloxifene standing out as the best gynecomastia solution, and Enclomiphene being the best option to increase/stabilize testosterone levels and Post-Cycle Therapy (PCT).
For in-depth information on each SERM, be sure to check out our SERM profiles.
WHERE TO BUY SERMS
Now that we’ve reviewed the best SERMs on the market in 2023, let’s explore the best SERM websites, and we’ll tell you who we think the best companies are in 2023.
All of the vendors on this list have been carefully picked by our team, and every one of them ensures high-purity active ingredients, moneyback guarantees, and touts high customer reviews.
1. AMINO ASYLUM
Getting a post cycle therapy from a high quality SARMs vendor is crucial.
Not all of these SARMs websites sell PCTs like Nolvadex.
One of the reasons we really like this company so much is because they have such a wide range of PCT products for sale. From research chemicals to therapeutic compounds, anabolic steroids, CBD oil, and more, their product catalog is STACKED.
Here’s why we like Amino Asylum:
- Competitive Prices
- One-Stop Shop
- Good Customer Support
- Fast Shipping
- High-Quality Products
Amino Asylum is definitely one of the newer SARMs and research chemical companies on the block but they’re very quickly starting to build up a good reputation for their company, due to many customers giving raving reviews for their products.
In addition to this, if you use the code “enhanced20” when purchasing, you’ll save 20% off your Nolvadex, your Clomid, and anything else you want to buy.
Our favorite vendor for getting a good PCT for your SARMs is Amino Asylum, they have both Nolvadex and Clomid for sale online.
Just one bottle of each will last the entire 4-week length for your SARMs post cycle therapy.
Here are the prices with a 20% discount of Amino Asylum PCTs for sale:
- Tamoxifen (Nolvadex) 20mg/mL = $23.99
- Clomiphene (Clomid) 20mg/mL = $19.99
- Enclomiphene 20mg/mL = $31.99
- Raloxifene 30mg/mL = $27.99
2. SWISS CHEMS
Swiss Chems is one of the best SARMs companies out there due to their product purity, great customer support, and competitive prices. They’ve got some of the best research chemicals on the market right now.
Here’s why we love Swiss Chems:
- Pharmacy Grade Products
- Third Party Tested For Purity
- Worldwide Shipping
- Competitive Prices
We asked for a coupon code to give you guys—use the code “enhanced10” for 10% off. This will apply to any of the SARMs, PCTs, or peptides that they’re selling on their site.
All of their PCTs for sale are third-party verified, meaning that every batch is tested by an independent laboratory to ensure at least 98%-99% purity.
Here are the prices with a 10% discount of Swiss Chems PCTs for sale:
- Clomiphene(Clomid) 25mg/cap = $62.95
- Tamoxifen (Nolva) 20mg/cap = $72
- Raloxifene 20mg/cap = $77.35
You can buy SARMs and peptides from them as well and for even cheaper if you choose the bulk options that they have for sale.
SUMMARY
In summary, it’s definitely best if you run a post cycle therapy for a SARMs cycle, to bring natural testosterone production back to normal.
Most people will keep around 75% of their gains if they do a good SARMs post cycle, like either Nolvadex or Clomid as we discussed up above here.
If you want to get 20% off Nolvadex, Clomid, and anything else, then just use the code “Enhanced20” at checkout and you’ll save money with this Amino Asylum coupon code.
POST CYCLE THERAPY FOR SARMs eBook
This Post Cycle Therapy for SARMs article provides a very general overview of SERMs.
For more information, check out THE SARM HANDBOOK we’ve written to give you everything you need to know in order to use SERMs & other Research Chemicals in the most effective and safest way possible.
Think of it like your personal cheat sheet for any cycle you have planned to know exactly each chemical you need from the start, during, and after your cycle.
Grab The SARM Handbook: the best guide to post cycle therapy for SARMs here